Carlton have sent a dagger through the hearts of Dockers fans scoring the match-winning goal in the last minute of the game.
The Blues booted five majors to three in the final term to score a 11.13.79 to 11.9.75 triumph.
Carlton hit the front twice during a seesawing final quarter but the Dockers looked like they had survived the scare when Sam Switkowki scored with under two minutes left in the game.
Incredibly Carlton found another avenue to goal through former skipper Marc Murphy sneaking it through the outstretched hands of the Dockers defence.
Cam McCarthy booted four goals in his return to the senior side while Michael Walters contributed with two majors.
Fremantle face West Coast next Saturday as derby rivalries reignite.