Traffic has been disrupted during peak-hour following the crash near the Kwinana freeway.
Both lanes of North Lake Road, from Elderberry Drive to Berrigan Drive, have been closed in South Lake following a crash.
Access is also reduced at Osprey Drive.
Emergency and towing services are on site but traffic heavy on approach.
Main Roads advises motorists to take caution on the roads.
Mandurah's Bar Therapy damaged by fire
Mandurah's Bar Therapy has been damaged by fire.
Postman injured in Wannanup crash
A postman has been taken to hospital following a crash in Wannanup.
Man charged after allegedly stealing service medals from Greenfields storage unit
Mandurah Police are asking for the public's help to recover a stolen set of service medals.
South West resort receptionist charged with 32 fraud offences
A South West resort employee has been charged after allegedly using guests credit card details to purchase items and accessing the retreat's eftpos machine to refund money into her own bank account.
Daughter of Port Kennedy hit-and-run victim pleads for offenders to hand themselves in
The daughter of a Port Kennedy hit-and-run victim is pleading for the two offenders to hand themselves in.
Concerns for missing woman last seen in Mandurah
Mandurah Police are urgently seeking the whereabouts of a 31-year-old woman who has not been seen for four days.
Mandurah woman wanted for questioning over current investigation
Mandurah Police are urgently looking for a 35-year-old woman who is wanted for questioning over a current investigation.
Investigation underway into Bunbury sexual assault
Detectives are continuing their investigation into the alleged sexual assault of a 17-year-old girl in Bunbury.
Two motorcyclists seriously injured in separate crashes
Two motorcyclists have suffered serious injuries in separate crashes in Perth and the South West.